A Site’s Guide to Managing Study Delays, Holds, and Cancellations
Study delays, holds, and cancellations increased 105% in 2025 compared to 2024, representing one of the most significant operational challenges facing research sites today.
These disruptions extend beyond sponsor and CRO impacts. Research sites face substantial financial losses, operational setbacks, and reputational damage. Sites invest significantly in staffing, infrastructure, and study preparation, yet often receive no compensation for rework, retraining, or refreshing costs when studies are delayed or cancelled.
The consequences compound beyond immediate financial impact. Sites experience erosion of trust with referral sources and community partners. Participants lose momentum and confidence in both individual sites and the broader clinical trials industry. Rebuilding this trust requires considerable time and resources.
Strategic Risk Management for Sites
While no single indicator perfectly predicts study disruptions, sites can implement proactive risk assessment strategies to protect their operations and patient populations.
This comprehensive guide provides actionable strategies developed by large, sophisticated research site networks, including:
- Financial vetting methods for sponsors and CROs
- Key risk indicators to monitor throughout study lifecycle
- Operational strategies to minimize financial and reputational exposure
- Best practices for maintaining stakeholder relationships during disruptions
Download the guide to access evidence-based strategies for navigating study disruptions and building operational resilience.
